Zinedine Zidane’s squad underwent the latest round of testing for COVID-19 on Monday after returning from a brief holiday period when the positive result was returned.
Forward Mariano Diaz is the player in question and is now self-isolating. He will miss the trip to the Etihad Stadium as a result.
A statement from Los Blancos read: “After the COVID-19 tests carried out yesterday on our first football team footballers by the Real Madrid medical services, our player Mariano has given a positive result.
“The player is in perfect health and complying with the sanitary isolation protocol at home.”
Mariano, 26, is a fringe member of Zidane’s squad having been limited to seven appearances in all competitions this season.
City are set to host La Liga’s champions on Friday, August 7 (8pm).
It was feared the tie would be in doubt due to the UK Government’s decision to impose a two-week quarantine period on people arriving from Spain due to a spike in coronavirus.
Real’s players and staff will be made exempt from the ruling, however.
The Department for Digital, Culture, Media and Sport will continue with guidelines enabling selected sporting events to continue as long as exempted individuals live and work in controlled bubbled environments behind closed doors.
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The winning team will progress to face Lyon or Juventus in the quarter-finals.
City are desperate to win the competition, having only secured the EFL Cup so far this season.
But Guardiola will not have Sergio Aguero available for the second leg.
“No, I think it will not be possible for the timing,” Guardiola said.
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